Definition of endogenous cannabinoids
ENDOGENOUS CANNABINOIDS ARE SUBSTANCES WITH MARIJUANA-LIKE EFFECTS AND STRUCTURE THAT ARE PRODUCED IN THE BRAIN. THEY ARE ALSO CALLED ENDOCANNABINOIDS. THE MAIN ENDOCANNABINOIDS ARE ANANDAMIDE AND 2-ARACHIDONOYL GLYCEROL (2-AG).
what it is
Endogenous cannabinoids are substances with marijuana-like effects and structure that are produced in the brain. Endogenous cannabinoids have a role in inhibiting the strength of synaptic transmission in neurons. They are involved in a variety of functions, including regulation of neural activity, retrograde synaptic transmission, stress response and diabetes.
How it is made
ENDOGENOUS CANNABINOIDS ARE PRODUCED IN THE BODY. ALTHOUGH THE SPECIFIC MECHANISM OF PRODUCTION IS NOT YET FULLY UNDERSTOOD, THEY ARE SYNTHESIZED IN SPECIFIC CELLS IN THE BRAIN AND ACT BY BINDING TO CANNABINOID RECEPTORS. BY INTERACTING WITH THE ENDOCANNABINOID SYSTEM (ECS), THEY PLAY A ROLE IN HELPING TO REGULATE FUNCTION AND HOMEOSTASIS.
neuronal activity regulation
Endogenous cannabinoids are responsible for inhibiting the strength of synaptic transmission in neurons. This action regulates neural activity and controls the transmission of information in the brain. Involved in the regulation of neural activity, they are also involved in the regulation of pain perception and sleep quality.
Stress response and diabetes
Endogenous cannabinoids are also involved in the stress response and the development of diabetes. During stress, the production of endogenous cannabinoids increases and exerts a stress-reducing effect. It has also been suggested that the involvement of endogenous cannabinoids increases the risk of developing diabetes. When endogenous cannabinoids do not function properly, the prevention and treatment of diabetes may be affected.
The above is a description of the role and function of endogenous cannabinoids. Endogenous cannabinoids are marijuana-like substances produced in the brain and have been implicated in the regulation of neural activity, retrograde synaptic transmission, and effects on stress response and diabetes.
Endogenous cannabinoids and marijuana
Endogenous cannabinoids are substances with effects and structures similar to those of marijuana and are produced in the brain. However, there are several differences between endogenous cannabinoids and marijuana.
Differences from marijuana
First, endogenous cannabinoids are produced by the body, whereas marijuana is extracted from the cannabis plant. In addition, endogenous cannabinoids are present in certain cells and organs in the body and are responsible for signal transduction between neurons in the brain. Marijuana, on the other hand, is externally ingested and acts by binding to cannabinoid receptors.
Research Trends in Endogenous Cannabinoids
CURRENTLY, THERE IS A LOT OF RESEARCH ON ENDOGENOUS CANNABINOIDS. IN PARTICULAR, ANANDAMIDE AND 2-ARACHIDONOYL GLYCEROL (2-AG) ARE BEING STUDIED FOR THEIR ACTIONS AND BIOSYNTHETIC MECHANISMS.
About Anandamide and 2-Arachidonoyl Glycerol
ANANDAMIDE IS A TYPE OF ENDOGENOUS CANNABINOID THAT HAS A ROLE IN REGULATING SYNAPTIC TRANSMISSION IN NEURONS. ANANDAMIDE INTERACTS WITH THE ENDOCANNABINOID SYSTEM (ECS) AND IS INVOLVED IN THE REGULATION OF NEURAL ACTIVITY, PAIN RELIEF, AND REDUCTION OF ANXIETY AND DEPRESSION.
2-AG IS ANOTHER MAJOR ENDOGENOUS CANNABINOID AND, LIKE ANANDAMIDE, PLAYS A ROLE IN REGULATING SYNAPTIC TRANSMISSION IN NEURONS. 2-AG IS INVOLVED IN NEUROPROTECTIVE EFFECTS, SUPPRESSION OF INFLAMMATION, AND ANALGESIA, AND IS IMPORTANT IN MAINTAINING BALANCE IN THE NERVOUS SYSTEM.
Schematic diagram of endogenous cannabinoid formation mechanism
THE MECHANISM OF ENDOGENOUS CANNABINOID FORMATION IS STILL UNDER INVESTIGATION. HOWEVER, AS A GENERAL SCHEMATIC, ARACHIDONIC ACID IS RELEASED FROM PHOSPHOLIPIDS PRESENT IN THE CELL MEMBRANE WHEN CERTAIN NEURONS ARE ACTIVATED. ARACHIDONIC ACID IS THEN CONVERTED TO ENDOGENOUS CANNABINOIDS SUCH AS ANANDAMIDE AND 2-AG BY SPECIFIC ENZYMES.
In addition, endogenous cannabinoid production mechanisms are thought to involve synaptic transmission between neurons, regulation of neuronal activity, stress response, and inflammatory response, and future research is expected to elucidate the detailed mechanisms.
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